胆固醇抗原的发现与作用机理（原文链接：https://en.wikipedia.org/wiki/Anti-cholesterol）
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Anti-cholesterol 胆固醇抗原
Anti-cholesterol is a naturally occurring antibodyto cholesterolproduced by mammals. This antibody serves a ‘housekeeping’ or protective role for the host animal, helping to protect the animal from harmful forms of cholesterol such as LDLand VLDL.
胆固醇抗原是天然存在哺乳动物身体中的一种胆固醇抗原。该抗原为主人提供免受有害形式的胆固醇的伤害，如LDL（低密胆固醇）和VLDL（极低密胆固醇）。
Modes of Action
作用机理
An immunoglobulin protein, anti-cholesterolmay be found both in circulation as well as in the digestive tract.
胆固醇抗原，这种免疫球蛋白，可以在循环以及消化道中发现。
In circulation, this antibody binds selectively to the small, dense, oxidized cholesterol or oxysterolrich LDLs that are known to contribute to the development of atherosclerosis. The antibody does not bind the good forms of cholesterol such as HDL.
在循环中，该抗原选择性地结合那些帮助形成动脉粥样硬化的低密度胆固醇或氧化的低密度脂蛋白胆固醇。抗原不结合良好形式的胆固醇，如HDL（高密度胆固醇）。
In the gastrointestinal tract, the antibody acts as a cholesterol absorption inhibitor. The antibody selectively binds to oxysterolor oxidized-rich cholesterol micellesand prevents their uptake by the intestinal enterocyte. The antibody-bound micelle is then removed through fecal clearance.
在胃肠道中，抗原还可以作为胆固醇吸收抑制剂。抗原选择性地结合低密度胆固醇并阻止它们被肠内肠细胞吸收。然后通过粪便清除去除抗原结合的胶束。
References
参考文献
Dijkstra J, Swartz GM, Raney JJ, et al. (1996年9月). "Interaction of anti-cholesterol antibodies with human lipoproteins"《抗胆固醇抗体与人类脂蛋白的相互作用》. J. Immunol. 157(5): 2006–13. PMID8757321.
Horváth A, Füst G, Horváth I, et al. (2001年5月). "Anti-cholesterol antibodies (ACHA) in patients with different atherosclerotic vascular diseases and healthy individuals. Characterization of human ACHA.《抗胆固醇抗体（ACHA）在不同动脉粥样硬化性血管疾病患者和健康人群中的表征》. Atherosclerosis. 156(1): 185–92. doi:10.1016/s0021-9150(00)00630-4. PMID11369013.
Alving CR, Swartz GM, Wassef NM, et al. (1996年1月). "Immunization with cholesterol-rich liposomes induces anti-cholesterol antibodies and reduces diet-induced hypercholesterolemia and plaque formation"《用胆固醇富集的脂质体进行免疫可诱导抗胆固醇抗体并减少饮食诱导的高胆固醇血症和斑块形成》. J. Lab. Clin. Med. 127(1): 40–9. doi:10.1016/S0022-2143(96)90164-X. PMID8592095.
Golay A, Ferrara JM, Felber JP, Schneider H (1990年12月). "Cholesterol-lowering effect of skim milk from immunized cows in hypercholesterolemic patients".《高胆固醇血症患者免疫母牛脱脂奶的降胆固醇效果》”Am. J. Clin. Nutr. 52(6): 1014–9. PMID2239776.
Earnest CP, Jordan AN, Safir M, Weaver E, Church TS (April 2005). "Cholesterol-lowering effects of bovine serum immunoglobulin in participants with mild hypercholesterolemia"《胆固醇降低作用的牛血清免疫球蛋白参与者轻度高胆固醇血症》. Am. J. Clin. Nutr. 81(4): 792–8. PMID15817854.
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